Table 5.
Effect of RA on cerebral Evans blue extravasation and MPO activity in ischemia-reperfused rats
| Group | Dose (mg/kg) | Evans blue extravasation (μg/g wet weight) | MPO activity (U/g wet weight) |
|---|---|---|---|
| Control |
— |
0.59 ± 0.13 |
0.02 ± 0.01 |
| Diabetic |
— |
0.67 ± 0.18 |
0.03 ± 0.01 |
| Vehicle |
— |
3.93 ± 0.62# |
0.18 ± 0.04# |
| RA | 50 | 1.73 ± 0.42* | 0.09 ± 0.02* |
Data are means ± SD, with n = 5 for each group. #P <0.01 vs. diabetic animals; *P <0.01 vs vehicle-treated animals. Significance was determined by one-way ANOVA followed by Dunnett's test.