Table 1.

Parameters used in the deterministic and stochastic simulations

Parameter	Description	Value	Reference
Kd1	dissociation constant of LuxR to A	100 nM	[41]
$k_1^{-}$	unbinding rate of LuxR to A	10 min−1	estimated
Kd2	dissociation constant of LuxR·AI dimerization	20 nM	fitted
$K_2^{-}$	dissociation rate of dimer (LuxR·AI)2	1 min−1	estimated
kA	synthesis rate of A by LuxI	0.04 min−1	fitted
Kdlux	dissociation constant of (LuxR·AI)2 to the lux promoter	200 nM	fitted
$k_{\mathit{\text{lux}}}^{-}$	dissociation rate of (LuxR·AI)2 to the lux promoter	10 min−1	estimated
b	burst size	20	[38]
kR	transcription rate of luxR	200/bmin−1	fitted
kI	transcription rate of luxI	50/bmin−1	fitted
pR	translation rate of luxR mRNA	bdmRmin−1
pI	translation rate of luxI mRNA	bdmImin−1
αR	ratio between unactivated and activated rate of expression of luxR	0.001	fitted
αI	ratio between unactivated and activated rate of expression of luxI	0.01	fitted
dA	degradation rate of A (same inside and outside the cell)	0.001 min−1	[42]
$d_{C_2}$	degradation rate of (LuxR·AI)2	0.002 min−1	estimated
dC	degradation rate of LuxR·AI	0.002 min−1	estimated
dR	degradation rate of LuxR	0.002 min−1	estimated
dI	degradation rate of LuxI	0.01 min−1	estimated
dmR	degradation rate of luxR mRNA	0.347 min−1	[43]
dmI	degradation rate of luxI mRNA	0.347 min−1	[43]
D	effective diffusion rate of A through the cell membrane	10 min−1	[44]
τ	cell cycle duration (doubling time) in RM/succinate at 30 C	45 min	[10]
λ	relative weight between the det./sto. components of the cell cycle	0.8	[33,45]
V0	cell volume at the beginning of cell cycle	1.5 μm3	[46]
Vtot	total cell culture volume	2·10−4μl