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. Author manuscript; available in PMC: 2013 Oct 18.
Published in final edited form as: Cell Host Microbe. 2012 Oct 18;12(4):521–530. doi: 10.1016/j.chom.2012.09.004

Figure 6. Caper and IRSF1 regulate resistance to P. falciparum infection and AgDscam Ig exon specific implication in anti-P. falciparum defense.

Figure 6

(A) P. falciparum oocyst infection intensity in Caper and IRSF1 depleted mosquitoes. Graphic presentation is as described in Figure 1 and the statistical numbers are presented in Supplementary Table S6. ****: p<0.0001. (B) P. falciparum oocyst infection intensity in independent Caspar, Caper and AgDscam silenced, or co-silenced silenced (Caspar+AgDscam, Caper+AgDscam, Caspar+Caper) mosquitoes. *: p<0.05; **: p<0.01; ***: p<0.001; ****: p<0.0001. (C) Effect of total AgDscam or specific spliceform repertoire silencing on A. gambiae susceptibility to P. falciparum infection. Mosquito cohorts were treated with dsRNAs of GFP, AgDscam or AgDscam siRNAs for Ig exons 4.1 and 4.14, or a siRNA pool targeting Ig exons 4.1, 6.17 and 10.21. Points indicate the absolute value of oocyst counts in individual mosquitoes from 3 replicates, and horizontal red bars indicate the median value of oocysts. See also Table S6.