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. 2013 Apr 2;8(4):e60314. doi: 10.1371/journal.pone.0060314

Figure 3. Normal synaptic transmission and plasticity in GPR55 KO hippocampal CA1 pyramidal neurons.

Figure 3

(A) Input-output relationships in the Schaffer collateral pathway are identical between GPR55 KO and WT mice. (B) Paired-pulse ratios are similar between GPR55 KO and WT slices (PP10 ratios: WT = 0.97±0.03, KO = 0.96±0.03; PP20 ratios: WT = 1.25±0.02, KO = 1.22±0.03; PP50 ratios: WT = 1.36±0.02, KO = 1.36±0.02; PP100 ratios: WT = 1.29±0.01, KO = 1.28±0.02; PP 200 ratios ISI: WT = 1.14±0.01, KO = 1.12±0.01). (C–D) Summaries show long-term potentiation (LTP) induced by TBS (C), or HFS protocol (D) in both WT and GPR55 KO Schaffer collateral pathways.