Table 1. SMA plasma protein marker that regress to motor function (MHFMS).
| BforSMA LC/MS Markers | Correlation to MHFMS | ||
| Protein | Name | R-value | p-value |
| CILP2 | Cartilage intermediate layer protein 2 | 0.76 | <0.001 |
| TNXB | Tenascin XB | 0.72 | <0.001 |
| CLEC3B | Ctype lectin domain family 3, member B (tetranectin) | 0.65 | <0.001 |
| TNXB | Tenascin XB | 0.60 | <0.001 |
| ADAMTSL4 | ADAMTSlike 4 | 0.56 | <0.001 |
| THBS4 | Thrombospondin 4 | 0.52 | <0.001 |
| COMP | Cartilage oligomeric matrix protein | 0.52 | <0.001 |
| CRTAC1 | Cartilage acidic protein 1 | 0.48 | <0.001 |
| F13B | Coagulation factor XIII, B polypeptide | 0.46 | <0.001 |
| PEPD | Peptidase D | 0.44 | <0.001 |
| LUM | Lumican | 0.43 | <0.001 |
| CD93 | Complement component 1, q subcomponent, receptor 1 | 0.42 | <0.001 |
| Mixed complement C2/B | −0.41 | <0.001 | |
| APCS | Amyloid P component, serum | −0.39 | <0.001 |
| VTN | Vitronectin | −0.38 | <0.001 |
| DPP4 | Dipeptidylpeptidase 4 (CD26, adenosine deaminase complexing protein 2) | 0.38 | <0.001 |
| CRP | C-reactive protein, pentraxinrelated | −0.37 | <0.001 |
| HBB | Hemoglobin beta | −0.37 | <0.001 |
| GSN | Gelsolin | 0.37 | <0.001 |
| NCAM1 | Neural cell adhesion molecule 1 | 0.35 | <0.001 |
| CFI | I factor (complement) | −0.35 | <0.001 |
| APOA4 | Apolipoprotein AIV | 0.35 | <0.001 |
| VTN | Vitronectin | −0.35 | <0.001 |
| F13A1 | Coagulation factor XIII, A1 polypeptide | 0.35 | <0.001 |
| INHBC | Inhibin, beta C | −0.34 | <0.001 |
| RPS27A | Ubiquitin and ribosomal protein S27a precursor | −0.33 | 0.001 |
| CDH13 | Cadherin 13, Hcadherin (heart) | 0.33 | 0.001 |
| mixed Complement C2/B | −0.33 | 0.001 | |
| C2 | Complement component 2 | −0.33 | 0.001 |
| CP | Ceruloplasmin (ferroxidase) | −0.32 | 0.001 |
| HBA | Hemoglobin subunit alpha | −0.31 | 0.001 |
| QSOX1 | Quiescin Q6 | 0.31 | 0.001 |
| LRG1 | Leucine-rich alpha2-glycoprotein 1 | −0.30 | 0.002 |
| C9 | Complement component 9 | −0.30 | 0.002 |
| SERPINA10 | Serpin peptidase inhibitor, clade A (alpha1 antiproteinase, antitrypsin), member 10 | −0.30 | 0.002 |
| ALP | Alkaline phosphatase, liver/bone/kidney | 0.29 | 0.003 |
| mixed fc-gamma receptor III-A/B | 0.29 | 0.003 | |
| PROC | Protein C (inactivator of coagulation factors Va and VIIIa) | −0.28 | 0.003 |
| VCAM1 | Vascular cell adhesion molecule 1 | 0.28 | 0.003 |
| GAPDH | Glyceraldehyde-3-phosphate dehydrogenase | −0.28 | 0.004 |
| OMD | Osteomodulin | 0.27 | 0.006 |
| IGKVD41 | Immunoglobulin kappa variable 41 | −0.27 | 0.006 |
| IGFBP6 | Insulinlike growth factor binding protein 6 | 0.26 | 0.007 |
| PTPRG | Protein tyrosine phosphatase, receptor type, G | 0.26 | 0.008 |
| S100A9 | S100 calcium binding protein A9 (calgranulin B) | −0.26 | 0.008 |
| VNN1 | Vanin 1 | −0.26 | 0.008 |
| SERPIND | Serpin peptidase inhibitor, clade D (heparin cofactor), member 1 | −0.26 | 0.009 |
| CA1 | Carbonic anhydrase I | −0.25 | 0.009 |
| CTSD | Cathepsin D (lysosomal aspartyl peptidase) | −0.25 | 0.01 |
| HP | Haptoglobin | −0.25 | 0.011 |
| SELENBP1 | Selenium binding protein 1 | −0.25 | 0.011 |
| ORM2 | Orosomucoid 2 | −0.25 | 0.012 |
| PRDX2 | Peroxiredoxin 2 | −0.25 | 0.012 |
| AOC3 | Amine oxidase, copper containing 3 (vascular adhesion protein 1) | 0.25 | 0.012 |
| COL6A3 | Collagen, type VI, alpha 3 | 0.24 | 0.012 |
| Unidentified protein | −0.24 | 0.013 | |
| PZP | Pregnancyzone protein | −0.24 | 0.013 |
| COL6A1 | Collagen, type VI, alpha 1 | 0.24 | 0.014 |
| PARK7 | Parkinson disease (autosomal recessive, early onset) 7 | −0.24 | 0.014 |
| THBS1 | Thrombospondin 1 | −0.24 | 0.015 |
| CAT | Catalase | −0.24 | 0.016 |
| LCP1 | Lymphocyte cytosolic protein 1 (Lplastin) | 0.23 | 0.018 |
| AFM | Afamin | −0.23 | 0.021 |
| HPR | Haptoglobinrelated protein | −0.22 | 0.021 |
| SELL1 | Selectin L (lymphocyte adhesion molecule 1) | 0.22 | 0.023 |
| ENG | Endoglin | 0.22 | 0.023 |
| PFN1 | Profilin 1 | −0.22 | 0.026 |
| PI16 | Peptidase inhibitor 16 | 0.22 | 0.026 |
| SERPINA6 | Serpin peptidase inhibitor, clade A (alpha1 antiproteinase, antitrypsin), member 6 | 0.21 | 0.028 |
| Unidentified protein | −0.21 | 0.03 | |
| F9 | Coagulation factor IX | −0.21 | 0.03 |
| PROCR | Protein C receptor, endothelial | 0.21 | 0.031 |
| ORM1 | Orosomucoid 1 | −0.21 | 0.031 |
| NEO1 | Neogenin homolog 1 | 0.21 | 0.032 |
| MMRN2 | Multimerin 2 | 0.21 | 0.033 |
| LGB | Beta-lactoglobulin | −0.21 | 0.034 |
| CNTN4 | Contactin 4 | 0.21 | 0.035 |
| SHBG | Sex hormonebinding globulin | 0.20 | 0.038 |
| CA2 | Carbonic anhydrase II | −0.20 | 0.043 |
| IGFBP5 | Insulinlike growth factor binding protein 5 | −0.20 | 0.045 |
| PLTP | Phospholipid transfer protein | 0.20 | 0.046 |
| FGA | Fibrinogen alpha chain | −0.20 | 0.046 |
| Unidentified protein | 0.19 | 0.05 | |
| TPM4 | Tropomyosin 4 | −0.19 | 0.05 |
| DiscoveryMAP Markers | Correlation to MHFMS | ||
| Protein | Name | R-value | p-value |
| MB | Myoglobin | 0.57 | <0.001 |
| SPP1 | Osteopontin | 0.54 | <0.001 |
| AXL | AXL receptor tyrosine kinase | 0.44 | <0.001 |
| APSC | Amyloid P component, serum | −0.42 | <0.001 |
| CRP | C-reactive protein, pentraxinrelated | −0.41 | <0.001 |
| CCL22 | Chemokine (C-C motif) ligand 22 (macrophage derived chemokine) | −0.41 | <0.001 |
| THBD | Thrombomodulin | 0.40 | <0.001 |
| CALCA | Calcitonin | −0.40 | <0.001 |
| LEP | Leptin | −0.40 | <0.001 |
| NPPB | Brain natriuretic peptide b | 0.37 | <0.001 |
| MMP2 | Matrix Metalloproteinase 2 | 0.37 | <0.001 |
| CK | Creatine kinase muscle/bone | 0.36 | <0.001 |
| ACE | Angiotensin converting enzyme | 0.36 | <0.001 |
| FAPB3 | Fatty acid binding protein (heart) | 0.35 | <0.001 |
| CD40 | CD40 Ligand | −0.34 | <0.001 |
| MIF | Macrophage Migration Inhibitory Factor | −0.34 | <0.001 |
| ANGPT2 | Angiopoietin 2 | −0.33 | <0.001 |
| AHSG | Alpha-2-HS-glycoprotein (fetuin A) | −0.33 | 0.001 |
| CFH | Complement factor H | −0.33 | 0.001 |
| IL8 | Interleukin 8 | −0.32 | 0.001 |
| C3 | Complement component 3 | −0.32 | 0.001 |
| PPY | Pancreatic polypeptide | 0.31 | 0.001 |
| VEGFA | Vascular endothelial growth factor | −0.30 | 0.002 |
| TF | Transferrin | −0.29 | 0.002 |
| PGF | Placental growth factor | 0.29 | 0.002 |
| EGF | Epidermal growth factor | −0.29 | 0.002 |
| GSTA1 | Glutathione S transferase alpha | −0.29 | 0.002 |
| SOD1 | Superoxide dismutase 1 | −0.29 | 0.003 |
| VCAM1 | Vascular cell adhesion molecule 1 | 0.28 | 0.003 |
| PAI1 | Plasminogen activator inhibitor 1 | −0.28 | 0.004 |
| CSF1 | Macrophage colony stimulating factor 1 | 0.28 | 0.004 |
| S100A12 | S100 Protein A12 | −0.28 | 0.004 |
| VTN | Vitronectin | −0.27 | 0.004 |
| FASLG | Fas ligand | 0.26 | 0.006 |
| A1M | Alpha-1-microglobulin | −0.26 | 0.007 |
| AST | Astartate transaminase | 0.25 | 0.009 |
| ACCT | Alpha-1-antichymotrypsin | −0.25 | 0.01 |
| CCL3 | Chemokine (C-C motif) ligand 3 (Macrophage Inflammatory Protein 1 beta) | −0.25 | 0.011 |
| SORT1 | Sortilin | −0.24 | 0.013 |
| TBG | Thyroxine binding globulin | −0.24 | 0.014 |
| APOA1 | Apolipoprotein A1 | 0.24 | 0.015 |
| MPO | Myeloperoxidase | −0.23 | 0.016 |
| B2M | Beta 2 microglobulin | 0.23 | 0.016 |
| EPO | Erythropoietin | −0.23 | 0.017 |
| MMP10 | Matrix Metalloproteinase 10 | −0.23 | 0.02 |
| PROS1 | Vitamin K Dependent Protein S | −0.22 | 0.023 |
| MMP7 | Matrix Metalloproteinase 7 | −0.22 | 0.025 |
| AGER | Advanced glycosylation end products receptor | 0.21 | 0.029 |
| IL18 | Interleukin 18 | 0.21 | 0.033 |
| CCL11 | Chemokine C-C motif ligand 11 | −0.21 | 0.034 |
| IGA | Immunoglobulin A | −0.20 | 0.035 |
| C peptide | Proinsulin C Peptide | −0.20 | 0.041 |
| A2M | Alpha-2-macroglobulin | −0.20 | 0.041 |
| PDGF BB | Platelet Derived Growth Factor | −0.20 | 0.042 |
| CCL16 | Chemokine C-C motif ligand 16 | −0.19 | 0.047 |
| IL1A | Interleukin 1 alpha | 0.19 | 0.049 |
| APOA4 | Apolipoprotein A4 | 0.19 | 0.049 |
| MMP9 | Matrix metalloproteinase 9 | −0.19 | 0.05 |
| OncologyMAP Markers | Correlation to MHFMS | ||
| Protein | Name | R-value | p-value |
| SPP1 | Osteopontin | 0.53 | <0.001 |
| CLEC3B | Ctype lectin domain family 3, member B (tetranectin) | 0.51 | <0.001 |
| IGFBP6 | Insulin-like growth factor binding protein 6 | 0.48 | <0.001 |
| FABP4 | Fatty acid binding protein (adipocyte) | −0.45 | <0.001 |
| CHI3L1 | Chitinase 3-like 1 (YKL-40) | −0.41 | <0.001 |
| LEP | Leptin | −0.39 | <0.001 |
| CTSD | Cathepsin D | −0.33 | 0.001 |
| MST1 | Macrophage stimulating 1 (hepatocyte growth factor-like) | −0.33 | 0.001 |
| MIF | Macrophage migration inhibitory factor | −0.32 | 0.001 |
| S100A4 | S100 calcium binding protein A4 | −0.32 | 0.001 |
| GLO1 | Glyoxalase 1 (lactoylglutathione lyase) | −0.32 | 0.001 |
| ENG | Endoglin | 0.30 | 0.001 |
| FTL1 | Fms-related tyrosine kinase 1 (vascular endothelial growth factor receptor) | −0.30 | 0.002 |
| ERBB2 | Human epidermal growth factor receptor 2 (HER2) | −0.28 | 0.003 |
| NDKB | Nucleoside phosphatase kinase isoform B | −0.28 | 0.004 |
| PRDX-4 | Peroxiredoxin 4 | −0.25 | 0.01 |
| PLAUR | Plasminogen activator, urokinase receptor | −0.24 | 0.015 |
| IL6R | Interleukin 6 receptor | 0.23 | 0.02 |
| CCL24 | Chemokine (C-C motif) ligand 24 (eotaxin 2) | −0.21 | 0.034 |
| GSN | Gelsolin | 0.20 | 0.038 |
| PSAT1 | Phosphoserine aminotransferase 1 | −0.20 | 0.039 |
| TGFB1 | Transforming growth factor beta 1 | −0.19 | 0.049 |
Markers that regressed to MHFMS SMA motor scores from the BforSMA study are listed by each analysis with their R-values and p–values. TNXB appears twice due to the positive regression with two unique isoforms.