Table 4. SMA non-motor outcome regressors.

Outcome Measure	Analyte	R-value	p-value
CHOP-TOSS	ERBB2	0.597	0.002
	IL10	0.432	0.035
	IL18	0.422	0.04
	IGFBP1	0.41	0.046
	GOT1	0.412	0.046
	INS	−0.405	0.049
FVC	MB	0.52	0
	TNFR2	0.432	0.001
	A2M	−0.374	0.005
	CCL4	0.339	0.011
	RSTN	0.328	0.013
	TNFRI	0.33	0.013
	IGFBP5	−0.323	0.015
	FRTN	0.306	0.022
	UPA	−0.303	0.023
	pINS	0.3	0.024
	AXL	0.273	0.042
	TIMP1	0.27	0.044
	FBLN1C	−0.264	0.049
	IL10	0.264	0.049
CMAP	DPP4	0.261	0.022
	ADIPOQ	−0.256	0.025
	APOB	−0.252	0.027
	pINS	0.246	0.031
	CCL4	−0.245	0.032
	LUM	0.244	0.033
	PPY	0.238	0.037
	IL12P40	−0.236	0.039
	MMP7	−0.236	0.039
	VWF	0.236	0.039
	PEPD	0.226	0.048
MYOEF	MB	0.455	<0.001
	PEPD	0.385	0.002
	pINS	0.298	0.018
	A2M	−0.274	0.031
	DPP4	0.274	0.031
	pINS (total)	0.271	0.033
MYOKF	pINS	0.398	0.002
	pINS (Total)	0.345	0.008
	MB	0.311	0.017
	INS	0.306	0.019
	IGFBP1	−0.27	0.038
	PEPD	0.27	0.038
	DPP4	0.261	0.046
	COMP	0.259	0.047
MYOKE	COMP	0.421	0.001
	LUM	0.41	0.001
	TG	−0.394	0.002
	PEPD	0.38	0.003
	MB	0.36	0.005
	DPP4	0.321	0.012
	FBLN1C	−0.324	0.012
	APOB	−0.32	0.013
	PGI	−0.32	0.013
	MMP9	−0.297	0.021
	ANG	−0.292	0.024
	THBS4	0.278	0.032
	TNXB	−0.276	0.033
	MSP	−0.269	0.038
	CD93	0.264	0.042
	FRTN	0.263	0.043
PQP	AXL	0.394	0.001
	DPP4	0.297	0.012
	ADIPOQ	−0.294	0.013
PQC	CD93	0.456	0.001
	FASLR	0.424	0.002
	CLEC3B	0.367	0.007
	INS	0.27	0.05

Several markers were identified in the PNCR NHS as regressing to the Children’s Hospital of Philadelphia Test of Strength (CHOP-TOSS), pulmonary function (best FVC), electrophysiology (CMAP and MUNE), strength as measured by knee and elbow flexion and extension(log average MyoEF, MyoKE, MyoKF), parent-reported and child-reported quality of life (PQP and PQC).