Table 5. SMA-MAP analytes and their correlated outcomes.

Analyte	Correlated Outcome Measures
APOB	CMAP, Strength
APCS	Motor
ASHG	Motor, PD, CMAP, Strength
AXL	FVC, Motor, PD?, PQP
CCL2	PD?
CD93	Motor, MUNE, PQC, Strength
CFH	Motor
CDH13	Motor
CHI3L1	Motor
CLEC3B	Motor, PQC
COMP	Motor, MUNE, Strength
CRP	Motor, PD?
CTSD	Motor
DPP4	Motor, MUNE, PQP, Strength
ENG	Motor, PD?
ERBB2	CHOP-TOSS, Motor, PD?
FBLN1	FVC, Motor, PD?, Strength
IGF1	PD?
IGFBP6	Motor, PD?
LEP	Motor
LUM	CMAP, Motor, MUNE, PD? Strength
MB	FVC, Motor, Strength
PEPD	CMAP, Motor, MUNE, Strength
PGF	Motor, MUNE, PD?
SPP1	Motor
THBS4	Motor, MUNE, PD?
TNXB	Motor

CHOP-TOSS = Children’s Hospital of Philadelphia Test of Strength, FVC = forced vital capacity, Motor = motor function scale (e.g. MHFMS, HFMS, HFMSE, GMFM), PD = SMN pharmacodynamic measure, CMAP = compound motor action potential, MUNE = motor unit number estimation, PQP = PedQL quality of life, parent score, PQC = PedQL quality of life, child score, CHOP-TOSS = Children’s Hospital of Philadelphia Test of Strength.