Table 1. Pancreatic exocrine function in chow-fed TgCEL and control mice at 7 months of age.
Males | Females | |||||
Controls | TgCEL | P | Controls | TgCEL | P | |
Serum lipid levels | ||||||
Total serum cholesterol (mg/dL) | ||||||
Fasting | 125±17 | 106±5 | ns | 88±5 | 92±10 | ns |
Fed | 163±13 | 158±31 | ns | 122±26 | 135±21 | ns |
Serum triglycerides (mg/dL) | ||||||
Fasting | 107±13 | 92±8 | ns | 77±14 | 74±12 | ns |
Fed | 119±18 | 111±16 | ns | 70±23 | 71±22 | ns |
Free fatty acids (mEq/L) | ||||||
Fasting | 1.6±0.1 | 1.4±0.2 | ns | 1.0±0.1 | NA | |
Fed | 1.3±0.2 | 1.1±0.2 | ns | 1.0±0.2 | 0.9±0.2 | ns |
Exocrine pancreatic function | ||||||
Serum amylase, fasting | 1344±114 | 1197±101 | ns | 1057±90 | NA | |
Fat absorption (%) | 94±2 | 93±2 | ns | 98±0,46 | 99±0,27 | ns |
Fat excretion (%) [60%HFD, n = 2] | 4.5±1.0 | 8.1±0.9 | ns | 7.5±1.6 | 6.0±0.1 | ns |
Fecal elastase (milliU/g) | 8.9±3.0 | 7.5±2.1 | ns | 14.2±4.7 | 21.1±7.4 | ns |
Vitamin A, retinol (µg/dL) | 38±7 | 30±3 | ns | 18±1,2 | 18±0,42 | ns |
Vitamin E, α-tocopherol (µg/dL) | 387±37 | 371±22 | ns | 462±30 | 432±32 | ns |
Vitamin E/total cholesterol ratio | 3.0±0.4 | 2.6±0.3 | ns | 3.6±0.23 | 3.7±0.72 | ns |
Values are mean ± SEM; ns, not significant; NA, not available.