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. Author manuscript; available in PMC: 2014 Jul 15.

Published in final edited form as: Biol Psychiatry. 2012 Dec 27;74(2):99–105. doi: 10.1016/j.biopsych.2012.10.032

Table 1.

Behavioral and neural predictors of amphetamine-induced cognitive flexibility.

	d-AMPH Switch Cost Reduction
	Step 1	Step 2	Step 3
Placebo Switch Cost	0.52 (0.14)	0.30 (0.12)	0.26 (0.12)
	3.64^***	2.51^*	2.29^*
Thalamic-Cortical DA BP_ND	—	0.76 (0.16)	0.54 (0.18)
		4.86^***	3.10^**
Caudate DA Release	—	—	0.30 (0.13)
			2.30^*
Age	−0.07 (0.15)	0.17 (0.13)	0.09 (0.12)
	−0.49	1.31	0.74
Sex	−0.03 (0.14)	−0.13 (0.11)	−0.11 (0.11)
	−0.21	−1.12	−1.02
Scanner	0.05 (0.15)	0.25 (0.12)	0.21 (0.12)
	0.34	1.97	1.80
R²	.29^*	.58^***	.64^***
Adjusted R²	.21^*	.52^***	.57^***
Observations	40	40	40

BP_ND = binding potential, non-displaceable. top: coefficient (s.e.m.); bottom: t-statistic,

^*

p<.05,

^**

p<.01,

^***

p<.001