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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Eur Urol. 2012 Sep 5;63(5):920–926. doi: 10.1016/j.eururo.2012.08.053

Fig. 3.

Fig. 3

(a) Clinically localized prostate cancer Gleason grade 6 (3 + 3) with Paneth cell–like neuroendocrine differentiation (upper inset); BRAF-EPB41 gene fusion was identified in this case by sequencing and was validated by fluorescence in situ hybridization(lower inset showing breakapart of the BRAF gene); (b) diagrammatic representation of novel BRAF rearrangement illustrating preserved kinase domain.