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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Semin Cancer Biol. 2013 Jan 14;23(2):80–89. doi: 10.1016/j.semcancer.2013.01.001

Figure 1.

Figure 1

Acquired alterations in DNA replication timing in cancer cells. A) Examples of individual loci that display a shift in replication timing. Loci that shift to an earlier time of replication are indicated in green, and regions that shift to a later time of replication are indicated in red. Three different chromosomes are shown. B) An example of an individual chromosome with a chromosome-wide delay in replication (red). Two chromosomes with normal replication timing are shown in grey.