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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Am J Geriatr Psychiatry. 2013 Feb 6;21(5):10.1016/j.jagp.2013.01.040. doi: 10.1016/j.jagp.2013.01.040

FIGURE 3. Over-representation of MDD effects in gene set displaying age-dependent changes in controls.

FIGURE 3

The histogram shows the relative proportion of genes showing age-effects in the amygdala of control subjects (Age-dependent, Dark blue, ~10%). The lower pie-chart indicates that 42% of the age-dependent genes in controls are also differentially expressed in MDD subjects (Based on List # 1, See methods). ***p<0.0001; Chi-square analysis comparing frequency of genes differentially expressed in MDD in the age-dependent genes selection compared to their frequency in the whole dataset. The upper pie-chart indicates that the frequency of MDD effect in the set of genes that are age-independent was nominally greater, but not significant different, from the control population.