Figure 2. ocm antagonizes MSL activity.

A. The male-specific lethal phenotype of hypomorphic ocm alleles are rescued by reducing levels of MSL subunits. Mutant male viability relative to brothers carrying CyO balancer. B. Two different hypomorphic alleles of msl1 are viable when homozygous but dead when hemizygous [14]. Both alleles are partially rescued by reducing ocm activity. Viability of males is shown relative to sisters of the same genotype. C. roX1 roX2/Y; [w⁺ GMroX1-75C] females were mated to males donating either the msl1 ^L60 null allele (Df), or males carrying both msl1 ^L60 and the indicated ocm allele. Male viability relative to sisters with same autosomal genotype. Trials indicate independent crosses examined. N indicates number of relevant control siblings used to calculate viability. p values calculated by Fisher exact test.