Table 5.
Treatment results according to presented features in all children treated in AML-BFM 2004 Interim study
Factors | No. of total patients | Overall survival ± SE (%) | Event-free survival ± SE (%) | No. of patients with achieved CR (%) | Relapse-free survival ± SE (%) | |||
---|---|---|---|---|---|---|---|---|
5 year | p-value | 5 year | p-value | 5 year | p-value | |||
Gender | ||||||||
Male | 130 | 63.9 ± 4.5 | 0.59 | 54.6 ± 4.6 | 0.24 | 119 | 62.5 ± 4.8 | 0.51 |
Female | 107 | 62.1 ± 4.9 | 48.5 ± 5.1 | 88 | 65.3 ± 5.8 | |||
Age at diagnosis (year) | ||||||||
< 2 | 40 | 57.4 ± 7.8 | 0.47 | 45.7 ± 8.2 | 0.46 | 36 | 58.2 ± 9.2 | 0.36 |
2–10 | 62 | 68.5 ± 6.2 | 50.4 ± 6.6 | 53 | 63.7 ± 7.1 | |||
> 10 | 135 | 62.5 ± 4.5 | 54.3 ± 4.6 | 118 | 65.3 ± 4.9 | |||
WBC ´ 109 | ||||||||
< 20 | 121 | 68.6 ± 4.5 | 0.31 | 62.3 ± 4.6 | 0.026 | 110 | 75.9 ± 4.6 | 0.003 |
20–100 | 75 | 56.8 ± 6.1 | 40.8 ± 6.2 | 63 | 50.2 ± 7.0 | |||
> 100 | 41 | 58.4 ± 8.0 | 40.9 ± 8.1 | 34 | 50.6 ± 9.4 | |||
FAB type | ||||||||
M0 | 21 | 66.9 ± 11.4 | 0.07 | 63.5 ± 11.3 | 0.16 | 18 | 67.9 ± 12.1 | 0.09 |
M1 | 32 | 63.3 ± 9.6 | 55.4 ± 9.5 | 28 | 65.2 ± 10.2 | |||
M2 | 66 | 68.7 ± 6.1 | 52.2 ± 6.3 | 62 | 61.3 ± 6.7 | |||
M3 | 20 | 74.6 ± 9.8 | 64.0 ± 12.9 | 16 | 82.9 ± 11.3 | |||
M4 | 48 | 66.2 ± 6.9 | 52.6 ± 7.4 | 43 | 65.6 ± 7.8 | |||
M5 | 36 | 43.9 ± 8.7 | 31.3 ± 8.4 | 29 | 42.9 ± 10.6 | |||
M6 + M7 | 14 | 53.8 ± 13.8 | 53.8 ± 13.8 | 11 | 88.9 ± 10.4 |
The values in italics denotes close statistical significance