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. 2013 Jan 14;43(3):705–715. doi: 10.1002/eji.201242794

Figure 1.

Figure 1

Foxp3+ Treg cells and Foxp3− Teff cells increase expression of ICOS in response to helminth infection. C57BL/6 mice were infected with H. polygyrus or S. mansoni and the expression of ICOS by CD4+Foxp3+ Treg cells and CD4+Foxp3− Teff cells assessed over time. (A) Representative staining for Foxp3 and ICOS on MLN CD4+ T cells from naïve and H. polygyrus-infected mice 14 day pi. (B, C) Percentage of CD4+Foxp3− cells expressing ICOS from (B) the MLNs of H. polygyrus-infected mice and (C) spleen of S. mansoni-infected mice. (D, E) Percentage of CD4+Foxp3+ cells expressing ICOS from (D) the MLNs of H. polygyrus-infected and (E) spleen of S. mansoni-infected mice. Symbols denote individual naïve (open) and infected (closed) mice, and lines denote means (B, D) or medians (C, E). Results show one representative experiment of two performed for each time point. *p < 0.005 (ANOVA using combined data from two separate experiments). §p < 0.05 (Mann–Whitney).