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IL-10 affects maturation and induces tolerogenic DC. (A) Presence of IL-10 during the maturation process of immature DC impairs the upregulation of costimulatory molecules like CD80 and CD86 resulting in the tolerogenic phenotype of IL-10DC. (B) Tolerogenic IL-10DC display a reduced T cell stimulatory capacity compared to immunogenic DC (left) and induce T cell anergy, displayed by reduced T cell proliferation after polyclonal restimulation (right).
