Figure 2.

Skeletal muscle fatty acid oxidation. Fifty-two individuals with T2D were randomized to 1 of 4 groups for a 9-month intervention and underwent skeletal muscle biopsies at baseline and 9 months: nonexercise control (n = 10), AT (n = 12), RT (n = 18), and ATRT (n = 12). A and B, Long-chain fatty acid oxidation to CO₂ was assessed using [1-¹⁴C]palmitate for complete oxidation (A) and the ratio of complete to incomplete oxidation (B). C, Medium-chain fatty acid oxidation to CO₂ was measured using [1-¹⁴C]octanoate. Data are presented as mean ± SEM. All substrate oxidation data were not normally distributed. *P < .05; **P < .01 vs control; $P < .05 vs RT.