Figure 4.

Changes in mitochondrial content related to changes in clinical and functional outcomes. Fifty-two individuals with T2D were randomized to 1 of 4 groups for a 9-month intervention and underwent skeletal muscle biopsies at baseline and 9 months. We collapsed the exercise groups and performed Spearman correlation analyses: AT (n = 12), RT (n = 18), and ATRT (n = 12). A–D, We present the relationships between the changes in mtDNA copy number and the changes in VO₂peak (A), HbA_1c (B), BHAD activity (C), and palmitate oxidation to CO₂ (D). The mtDNA copy number and palmitate oxidation data were not normally distributed.