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. 2013 Mar 1;3(3):e103. doi: 10.1038/bcj.2013.2

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Copyright © 2013 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Synergistic cytotoxicity of HIV-PI with bortezomib and carfilzomib. (a) AMO-1 cells were incubated with the respective HIV-PI (0–20 μℳ) in combination with bortezomib 0–5 nM (upper panel), or in combination with carfilzomib (0–5 nM, lower panel), and cell viability was assessed by dimethylthiazol-diphenyltetrazole test. (b) The synergistic cytotoxic effect of nelfinavir, lopinavir, saquinavir, ritonavir with bortezomib (a upper panel), in contrast to the other HIV-PI (Supplementary Figure 3), is statistically confirmed by Isolobograms (symbols below the dashed line statistically indicate synergism).