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. 2010 Dec;6(4):301–309.

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© Ching-Ting Lin et al. Licensee Master Publishing Group

This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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IGF-1 is cleaved by DPP-IV. Panel A: An IGF-1 peptide (10-mer) corresponding to the 10 amino-terminal residues was cleaved by DPP-IV, as shown by HPLC analysis. The original 10-mer is shown in blue, and its cleavage products in red. Panels B–D show a MALDI-TOF analysis of the full-length IGF-1 cleaved by DPP-IV or FAP after incubation for 16 h. Panel B: Full-length IGF-1 only. Panel C: Full-length IGF-1 incubated with DPP-IV. Panel D: Full-length IGF-1 incubated with FAP.