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. 2012 Apr 17;23(5):1118–1125. doi: 10.1093/cercor/bhs089

Figure 3.

Figure 3.

OR training and test impairs LTP in the CA1. (a) Application of 100 Hz HFS to the Schaffer collateral—CA1 stratum radiatum synapses in freely moving mice led to LTP (n = 10). When HFS was given simultaneously with OR training (OR A–B) and test (OR A–C), the potentiation was completely abolished (ANOVA, P < 0.0001) in both phases. The inhibition of LTP fell below basal levels and persisted for more than 24 h (1440 min). (b) Analog traces illustrate the Schaffer collateral—CA1 field potentials at pretask, 5 min and 24 h (1440 min). Vertical scale bar corresponds to 2 mV and horizontal scale bar corresponds to 5 ms. (c) Behavioral analysis showed that the mice performed the OR task successfully when given concurrently with HFS. The mice explored both objects A and B equally during the training phase but explored the novel object C to a significantly greater extent during the test phase. *t-test, P < 0.0001. (d) Analysis of the discrimination ratio revealed that the mice showed no preference for either object during the training phase but a strong preference for the novel object during the test phase (ANOVA, P < 0.0001).