Table 5. Enhancement ratiosa owing to combination with a 10B-carrier.
10B-carrier | Total cell population | Quiescent cells |
Surviving fraction=0.08 | ||
BPA | 1.95 (1.75–2.15)b | – |
BSH | 1.3 (1.2–1.4) | – |
Net micronucleus frequency=0.2 | ||
BPA | 2.0 (1.8–2.2) | 1.7 (1.6–1.8) |
BSH | 1.3 (1.2–1.4) | 1.8 (1.65–1.95) |
Net apoptosis frequency=0.06 | ||
In whole cell fraction | ||
BPA | 1.5 (1.4–1.6) | 1.25 (1.15–1.35) |
BSH | 1.4 (1.3–1.5) | 1.35 (1.2–1.5) |
In pimonidazole-unlabelled cell fraction | ||
BPA | 1.65 (1.5–1.8) | 1.65 (1.5–1.8) |
BSH | 1.5 (1.4–1.6) | 1.7 (1.6–1.8) |
BPA, boronophenylalanine-10B; BSH, sodium mercaptoundecahydrododecaborate-10B.
aThe ratio of the dose of radiation necessary to obtain each end point without a 10B-carrier to that needed to obtain each end point with a 10B-carrier.
bValues in parentheses are 95% confidence limits, determined using standard errors. When the ranges of 95% confidence limits showed no overlap between two values, the difference between the two values were significant (p<0.05) based on a χ2 test.