Skip to main content
. Author manuscript; available in PMC: 2013 Apr 3.
Published in final edited form as: Nature. 2012 Aug 30;488(7413):647–651. doi: 10.1038/nature11310

Figure 4. Rapamycin treatment prevents pathologic and behavior abnormalities in PC Tsc1 mutant mice.

Figure 4

A. Treatment with rapamycin (Rapa) prevented cell loss seen in vehicle (Veh) treated PC Tsc1 mutants. Scale bar: 100 μm. Quantification of cell numbers on right (n > 500cells; 2 mice per group) B., C. Whereas vehicle treated mutants displayed behavioral deficits, rapamycin treated mutants displayed amelioration of these deficits in B. reversal learning in the water T maze (n≥9 in each group) and in C. social approach in the three chambered apparatus (n≥10). As behavioral phenotypes were not significantly different between the three control genotypes in untreated mice, control genotypes were pooled into a single group for these studies. ns, p>0.05; *, p<0.05; *** p <0.001, two-way ANOVA, Bonferroni's post hoc analysis.