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. Author manuscript; available in PMC: 2013 Apr 3.
Published in final edited form as: J Diabetes Metab. 2012 May 31;3(4):1000193. doi: 10.4172/2155-6156.1000193

Figure 4. STZ toxicity in high-density MIN6 cultures was attenuated by SIRT1 knockdown, and potentiated by SIRT1 overexpression.

Figure 4

MIN6 cultures were exposed to 7.5 millimol/L STZ at high density. SIRT1 denotes the SIRT1 overexpressing line, and siRNA denotes the line which overexpresses the SIRT1 siRNA. Cell survival was assayed by 0.1% MTT staining. # signifies difference from STZ exposure alone; $ signifies difference from similarly exposed control cultures at P < 0.05. mM means millimol/L, STZ means streptozotocin.