Table 2.
Biodistribution comparison among 99mTc-MAG3-GGNle-CycMSHhex {MAG3}, 99mTc-AcCG3-GGNle-CycMSHhex {AcCG3}, 99mTc(CO)3-HYNIC-GGNle-CycMSHhex {(CO)3} and 99mTc(EDDA)-HYNIC-GGNle-CycMSHhex {EDDA} in B16/F1 melanoma-bearing C57 mice at 2 h post-injection. The data were presented as percent injected dose/gram or as percent injected dose (Mean ± SD, n=5)
| Tissues | MAG3 | AcCG3 | (CO)3 | EDDA |
|---|---|---|---|---|
| Percent injected dose/gram (%ID/g) | ||||
| Tumor | 4.64±1.06 | 9.76±0.51 | 5.84±1.26 | 14.14±4.90 |
| Brain | 0.05±0.05 | 0.04±0.03 | 0.12±0.02 | 0.05±0.04 |
| Blood | 0.25±0.13 | 0.27±0.13 | 2.17±1.91 | 0.17±0.05 |
| Heart | 0.33±0.13 | 0.27±0.14 | 1.94±0.22 | 0.09±0.03 |
| Lung | 0.46±0.10 | 0.47±0.09 | 4.42±1.62 | 0.41±0.06 |
| Liver | 1.18±0.15 | 1.69±0.35 | 38.11±2.31 | 0.52±0.05 |
| Spleen | 0.30±0.12 | 0.35±0.10 | 4.70±1.13 | 0.18±0.08 |
| Stomach | 3.38±0.78 | 2.86±1.80 | 4.01±1.78 | 1.02±0.31 |
| Kidneys | 1.20±0.51 | 2.62±0.45 | 17.69±4.06 | 7.52±0.96 |
| Muscle | 0.08±0.02 | 0.12±0.09 | 0.17±0.07 | 0.04±0.02 |
| Pancreas | 0.41±0.54 | 0.32±0.16 | 1.02±0.55 | 0.04±0.04 |
| Bone | 0.29±0.13 | 0.50±0.28 | 1.91±0.52 | 0.12±0.05 |
| Skin | 0.28±0.10 | 0.20±0.07 | 1.75±0.62 | 0.33±0.10 |
|
| ||||
| Percent injected dose (%ID) | ||||
| Intestines | 55.02±10.44 | 50.91±2.72 | 18.35±5.49 | 1.09±0.06 |
| Urine | 27.53±6.99 | 38.20±3.98 | 27.65±2.53 | 91.26±1.96 |