Table 2.
Transcription factor binding sites enriched in TEB versus duct
| # | Annotation | Total genes | Bayes factor |
|---|---|---|---|
| 1 | E2F1_Q6: E2F1 | 123 | 15.34 |
| 2 | KROX_Q6 | 101 | 13.37 |
| 3 | SOX9_B1: SOX (SRY-related HMG box) | 61 | 9.67 |
| 4 | SP3_Q3 | 138 | 9.39 |
| 5 | MRF2_01: modulator recognition factor 2 | 71 | 9.23 |
| 6 | MAZ_Q6 | 142 | 8.75 |
| 7 | E2F_Q3_01 | 86 | 8.48 |
| 8 | OCT1_06: octamer-binding factor 1 | 62 | 8.11 |
| 9 | MAZR_01: MAZ related factor | 98 | 8.07 |
| 10 | SOX5_01: SOX5 | 48 | 7.81 |
| 11 | E2F1_Q6_01 | 86 | 7.6 |
| 12 | POU6F1_01 | 1 | 6.57 |
| 13 | NMYC_01: N-MYC | 59 | 6.27 |
| 14 | ELK1_02: ELK1 | 148 | 5.59 |
| 15 | USF_01: upstream stimulating factor | 35 | 5.49 |
| 16 | E2F_Q4: E2F | 81 | 5.33 |
| 17 | NRF2_01: nuclear respiratory factor 2 | 48 | 5.33 |
| 18 | EVI1_04: ectopic viral integration site 1 encoded factor | 101 | 4.7 |
| 19 | E2F1_Q3_01 | 68 | 4.67 |
| 20 | MYC_Q2 | 51 | 4.61 |
From a dataset comparing microdissected TEBs to ducts, the expression of various genes was compared for fold change [log2(Cy5 TEB/Cy3 stroma) − log2(Cy5 duct/Cy3 stroma)]. For the top 200 genes elevated in the TEB sample, the genes were analyzed using GATHER to assess which transcription factor binding sites they contained based on the TRANSFAC database. The top 20 results are shown for these 200 genes, with the number of genes from this dataset and the significance indicated by the Bayes factor. E2F factors are in bold.