Table 1.

Serum parameters after 12-week administration of ECH.

Group	SHAM	OVX	E2	ECH-L	ECH-M	ECH-H
ALP (U/100 mL)	10.96 ± 1.36	14.76 ± 2.86##	11.66 ± 1.88*	12.20 ± 1.22*	12.00 ± 1.56*	10.95 ± 1.97**
TRACP-5b (U/L)	0.306 ± 0.026	0.367 ± 0.054#	0.294 ± 0.054*	0.277 ± 0.084*	0.231 ± 0.088**	0.227 ± 0.082**
OPG (pg/mL)	610.32 ± 85.29	516.36 ± 65.35#	621.41 ± 121.78*	631.77 ± 131.64*	729.42 ± 122.59**	775.29 ± 179.87**
RANKL (pg/mL)	6.44 ± 0.55	7.38 ± 0.83#	7.19 ± 1.75	6.38 ± 0.58*	6.15 ± 1.01*	5.75 ± 1.21**
OPG/RANKL ratio	95.09 ± 13.44	70.32 ± 8.53##	92.74 ± 35.72	100.75 ± 28.50*	121.41 ± 29.23**	138.98 ± 39.16**

The data are expressed as mean ± SD, n = 8. ^# P < 0.05 and ^## P < 0.01 versus SHAM group, *P < 0.05 and **P < 0.01 versus OVX group at the same time point as evaluated by ANOVA.