Table 2.
BMD, Micro-CT properties of femoral trabeculae and biomechanical test of femur after 12-week administration of ECH.
| Group | SHAM | OVX | E2 | ECH-L | ECH-M | ECH-H |
|---|---|---|---|---|---|---|
| BMD (g/cm2) | 0.28 ± 0.01 | 0.22 ± 0.01## | 0.26 ± 0.01** | 0.25 ± 0.01** | 0.26 ± 0.01** | 0.28 ± 0.01** |
| BV/TV (%) | 58.71 ± 6.38 | 16.42 ± 3.44## | 34.52 ± 3.38** | 23.22 ± 4.07* | 26.12 ± 2.02** | 28.80 ± 2.53** |
| Tb.N (1/mm) | 3.88 ± 0.25 | 2.18 ± 0.48## | 3.01 ± 0.10* | 2.76 ± 0.58 | 3.02 ± 0.38* | 3.12 ± 0.41* |
| Tb.Sp (μm) | 106.52 ± 14.78 | 452.02 ± 65.48## | 219.83 ± 9.99** | 355.04 ± 41.53* | 321.98 ± 28.59* | 279.57 ± 23.15** |
| Tb.Th (μm) | 152.28 ± 22.30 | 84.05 ± 7.19## | 114.24 ± 8.13** | 97.12 ± 7.47* | 112.06 ± 20.16* | 115.32 ± 10.79** |
| SMI | 0.78 ± 0.12 | 2.77 ± 0.49## | 1.41 ± 0.25** | 2.11 ± 0.15* | 1.90 ± 0.43* | 1.86 ± 0.17* |
| Maximum load (N) | 87.54 ± 5.86 | 60.00 ± 3.35## | 89.71 ± 6.45** | 83.05 ± 7.81** | 83.70 ± 6.49** | 93.31 ± 13.66** |
| Stiffness (N/mm) | 190.98 ± 36.03 | 147.56 ± 12.54# | 189.81 ± 18.33** | 173.17 ± 24.52* | 178.67 ± 18,55** | 197.79 ± 32.05** |
| Energy to ultimate load (millijoules, mJ) |
17.33 ± 2.58 | 12.00 ± 1.79## | 18.67 ± 3.01** | 25.67 ± 2.88** | 25.83 ± 3.13** | 34.00 ± 4.65** |
The data are expressed as mean ± SD, n = 6. # P < 0.05 and ## P < 0.01 versus SHAM group, *P < 0.05 and **P < 0.01 versus OVX group at the same time point as evaluated by ANOVA.