Table 1.
Upregulated plasma membrane receptor genes during megakaryocyte development
| Fold Change | Gene ID | Gene Identifier | Gene Title | Ligand |
|---|---|---|---|---|
| 55.9 | ITGB3 | M35999 | Integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | Fibronectin, ADAM15, ADAM23 |
| 17.2 | ITGA2B | AF098114 | Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) | Fibronectin 1, ICAM 4 |
| 16.8 | IL21R | NM_021798 | Interleukin 21 receptor | IL21 |
| 14.5 | LRP12 | NM_013437 | Low-density lipoprotein-related protein 12 | orphan receptor |
| 10.4 | ITGA6 | AV733308 | Integrin, alpha 6 | ADAM 2, ADAM9, DUSP18 |
| 9.0 | PTGER3 | L27489 | Prostaglandin E receptor 3 (subtype EP3) | Prostglandin E2 |
| 8.7 | CCRL2 | AF015524 | Chemokine (C-C motif) receptor-like 2 | orphan receptor |
| 8.6 | IL9R | NM_002186 | Interleukin 9 receptor | IL9 |
| 7.8 | ADAM10 | AU135154 | ADAM metallopeptidase domain 10 | orphan receptor |
| 7.2 | ITGB5 | NM_002213 | Integrin, beta 5 | ADAM9 |
| 7.1 | F2R | NM_001992 | Coagulation factor II (thrombin) receptor | Thrombin |
| 6.1 | HMMR | NM_012485 | Hyaluronan-mediated motility receptor (RHAMM) | Hyaluronan synthase 2 |
| 5.8 | PTGIR | NM_000960 | Prostaglandin I2 (prostacyclin) receptor (IP) | Prostacyclin |
| 5.2 | SELP | NM_003005 | Selectin P (granule membrane protein 140 kDa, antigen CD62) | Selectin P ligand, CD24 |
| 4.9 | SORT1 | BE742268 | Sortilin 1 | Nerve growth factor, beta subunit |
| 4.8 | THBD | NM_000361 | Thrombomodulin | Platelet factor 4 |
| 4.5 | CD40 | BF664114 | CD40 molecule, TNF receptor superfamily member 5 | CD40 ligand, lymphotoxin beta (TNF superfamily, member 3) |
| 4.0 | CSF2RB | AV756141 | Colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) | Granulocyte-macrophage colony stimulating factor, IL3, IL5 |
| 3.9 | C3AR1 | U62027 | Complement component 3a receptor 1 | complement component 3 |
| 3.8 | ICAM2 | NM_000873 | Intercellular adhesion molecule 2 | ITGAL, ITGB2 |
| 3.7 | ADRA2A | AF284095 | Adrenergic, alpha-2A-, receptor | Dopamine beta-hydroxylase, plasma |
| 3.7 | GPR137B | NM_003272 | G protein-coupled receptor 137B | orphan receptor |
| 3.5 | LRP8 | NM_004631 | Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor | orphan receptor |
| 3.1 | HTR2A | NM_000621 | 5-hydroxytryptamine (serotonin) receptor 2A | Tryptophan hydroxylase 1 |
| 3.0 | CD63 | NM_001780 | CD63 molecule | orphan receptor |
| 2.9 | TGFBR2 | D50683 | transforming growth factor, beta receptor II (70/80 kDa) | TGFb |
| 2.8 | CD47 | Z25521 | CD47 molecule | Thrombospondin I & II |
| 2.7 | IL6ST | AL049265 | Interleukin 6 signal transducer (gp130, oncostatin M receptor) | IL6, leukemia inhibitory factor, oncostatin M, ciliary neurotrophic factor, IL11, IL6, NP (ortholog of mouse neuropoietin) |
| 2.7 | ACVR1 | NM_001105 | Activin A receptor, type I | Bone morphogenetic protein 6 & 7 |
| 2.7 | ITGB1 | BG500301 | integrin, beta 1 | ADAM 12, 15, 17, 2, 9 |
| 2.5 | IL4R | NM_000418 | Interleukin 4 receptor | IL4, IL13 |
| 2.2 | TSPAN4 | AF054841 | Tetraspanin 4 | orphan receptor |
| 2.1 | CD55 | BC001288 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | CD97 |
| 2.0 | ADIPOR2 | NM_024551 | Adiponectin receptor 2 | Adiponectin, C1Q and collagen domain containing |
| 1.9 | IL10RB | BC001903 | Interleukin 10 receptor, beta | IL10 |
| 1.8 | SEMA4D | NM_006378 | Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D | Plexin B1 |
| 1.7 | PTPRA | AL121905 | protein tyrosine phosphatase, receptor type, A | orphan receptor |
| 1.6 | TSPAN31 | NM_005981 | Tetraspanin 31 | orphan receptor |
| 1.6 | TFG | NM_006070 | TRK-fused gene | orphan receptor |
| 1.6 | ATRN | AL132773 | attractin | Agouti signaling protein |
Fold change from 3 independent experiments; P value ≤ 0.01.