Fig. 3.

Effect of GSNOR inhibitor on blood pressure (BP) in hypertensive rats. A: BP measurements in anesthetized rats. n = 6 for each normotensive group; n = 7 for each hypertensive group. P < 0.05 for overall effect. B: BP measurements in conscious rats. N6338 reversed an increase in BP in the hypertensive rats (n = 10). *P < 0.001, high-salt vehicle (n = 7) vs. high-salt drug (n = 10). Values are means ± SD. Note that diastolic BP measurements by tail-cuff methodology are approximations and are included here for reference, while systolic values represent true measurements.