Fig. 6.

Effect of GSNOR inhibitor on the kidneys. A: at D14, kidney weights were increased in the high-salt vehicle group, while weights in the high-salt drug group trended lower. Values are means ± SD. B: there were no significant differences in heart weights among treatments. C: low-salt vehicle groups. D: low-salt drug groups. Histology of renal cortex shows normal glomerular (arrows) and tubular architecture (arrowheads) with back-to-back tubules, no interstitial edema, and intact tubular basement membrane, with no detectable difference between these low-salt groups. E: high-salt vehicle group. In contrast, histology of renal cortexes shows significant tubular swelling and dilation (asterisk), interstitial edema, loss of tubular brush borders, and basement membrane disruption (arrowheads), all of which were substantially reduced in rats treated with N6338 (F). Scale bar = 50 μm.