Fig. 3.

Time course of renal morphogenesis in wild-type mice. Kidneys from E10.5 (A), E12.5 (B), and E15.5 (C) embryos, and P0 (D) mouse were stained with hematoxylin and eosin. The ureteric bud (UB) is derived from the Wolffian duct (WD), and the metanephric mesenchyme (MM) is formed from the intermediate mesoderm. The condensed mesenchyme (CM) successively differentiates into the renal vesicle, which then proliferates to give rise to comma- and S-shaped bodies and glomeruli (G). Scale bar in (A)=50 µm (A.D).