Table 2.

Composition of formula.

Study ID	Formula	Composition of formula
Guo et al. 2002 [14]	ZGXFD	Achyranthes root, ruddle, dragon bone, oyster shell, plastrum testudinis, white peony root, radix scrophulariae, radix asparagi, fructus toosendan, raw malt, artemisia capillaris thunb, and glycyrrhiza.
Mao 2005 [15]	Modified ZGXFD	Achyranthes root 30 g, ruddle 30 g, uncaria 30 g (put in later), dragon bone 15 g, oyster shell 15 g, plastrum testudinis 15 g, white peony root 12 g, radix scrophulariae 12 g, radix asparagi 12 g, fructus toosendan 9 g, raw malt 20 g, artemisia capillaris thumb 9 g, and glycyrrhiza 6 g.
Luo 2008 [16]	ZGXFD	White peony root 30 g, radix asparagi 15 g, achyranthes root 30 g, ruddle 30 g, dragon bone 30 g, oyster shell 30 g, plastrum testudinis 25 g, radix scrophulariae 15 g, fructus toosendan 10 g, raw malt 10 g, artemisia capillaris thumb 15 g, and glycyrrhiza 10 g
Liu and Zhong 2008 [17]	Modified ZGXFD plus benazapril	White peony root 15 g, radix asparagi 15 g, plastrum testudinis 15 g, oyster shell 15 g, fructus toosendan 6 g, ruddle 30 g, achyranthes root 30 g, radix scrophulariae 15 g, dragon bone 15 g, artemisia capillaris thumb 6 g, raw malt 6 g, and glycyrrhiza 5 g. Severe headache plus chrysanthemum 10 g; insomnia plus pearl shell 15 g and caulis polygoni multiflori 15 g; vexation plus gardenia 10 g and scutellaria baicalensis georgi 10 g; severe phlegm-heat plus pinellia pedatisecta schott 6 g and fritillaria cirrhosa 10 g.
Li and Zheng 2012 [18]	Modified ZGXFD	Radix scrophulariae 15 g, ruddle 30 g, white peony root 15 g, achyranthes root 30 g, radix asparagi 15 g, dragon bone 15 g, oyster shell 15 g, raw malt 6 g, artemisia capillaris thumb 6 g, plastrum testudinis 15 g, fructus toosendan 6 g, and glycyrrhiza 3 g. Vexation plus plaster stone; abundant sputum plus pinellia pedatisecta schott and bamboo bark; slow-weak pulse plus prepared radix rehmanniae and pulp of cornus; diarrhea remove plastrum testudinis and ruddle, plus halloysitum rubrum; insomnia plus coptis chinensis, rehmanniae radix and caulis polygoni multiflori; severe headache plus abalone shell; severe dizziness plus gastrodia elata.
Zhou 2000 [19]	Modified ZGXFD plus nitrendipine	White peony root 20 g, radix asparagi 10 g, plastrum testudinis 5 g, oyster shell 30 g, abalone shell 20 g, ruddle 80 g, magnetite 30 g, achyranthes root 10 g, radix scrophulariae 15 g, salvia miltiorrhira 30 g, and panpax notoginseng 10 g. Severe headache plus antelope horn; insomnia plus pearl shell and caulis polygoni multiflori; vexation plus gardenia and scutellaria baicalensis georgi; severe phlegm-heat plus pinellia pedatisecta schott and fritillaria cirrhosa.