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. 2013 Feb 15;14(4):389–394. doi: 10.1038/embor.2013.15

Figure 3.

Figure 3

(S)-AMPA-induced neuronal tau release is regulated by intracellular calcium. (A) Tau secretion is induced by Iono (0.1 μM, 30 min), without any change in neuronal viability (B; MTS assay). (C) Treatment of neurons with the calcium chelator BAPTA-AM (1 μM) prevents (S)-AMPA (100 μM, 30 min) stimulation of tau release. (D) Tau release from neurons in calcium-free medium is blunted, although it remains significantly increased following (S)-AMPA (100 μM, 30 min), in the absence of cytotoxicity (E; MTS assay). Values represent mean±s.e.m. (N=6); *P<0.05, ***P<0.001. BAPTA-AM, 1,2-bis(o-aminophenoxy)ethane-N,N,N′,N′-tetraaceticacid-tetra(acetoxymethyl)ester; Iono, ionomycin; MTS, 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulphophenyl)-2H-tetrazolium; NS, not significant; (S)-AMPA, (S)-2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)-propanoic acid.