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. 2013 Feb 25;23(2):217–221. doi: 10.1111/bpa.12022

Figure 1.

figure

Isocitrate dehydrogenase (IDH) mutations result in glioma‐CpG methylation phenotype (G‐CIMP) and histone methylation in gliomas. Mutant IDH1 catalyzes the production of 2‐hydroxyglutarate (2‐HG) from α‐ketoglutarate (α‐KG). 2‐HG is thought to inhibit α‐KG‐dependent dioxygenase enzymes as 2‐HG is structurally similar to α‐KG. The Jumonji C family of histone lysine demethylases (KDMs) and the TET group of DNA hydroxylases are α‐KG‐dependent dioxygenases. Inhibition of these enzymes may result in increased histone methylation marks and DNA methylation contributing to G‐CIMP.