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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: J Cell Physiol. 2012 Aug;227(8):2992–3000. doi: 10.1002/jcp.24019

Figure 3. Nuclear translocation of IRS-1 in Medulloblastomas.

Figure 3

Immunohistochemistry for the IGF-IR/IR docking molecule, IRS-1, shows a prominent nuclear localization in clinical samples of medulloblastomas that express the JCV early oncoprotein, large T-antigen (upper panels). In T-antigen negative samples, IRS-1 remains in the cytoplasm of neoplastic cells (middle panels). In some tumors that lack T-antigen expression IRS-1 is still located to the nucleus in association with Estrogen Receptor beta (lower panels). Original magnification for all panels 600x.