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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: J Cell Physiol. 2012 Aug;227(8):2992–3000. doi: 10.1002/jcp.24019

Figure 4. Nuclear translocation of IRS-1 in Glioblastomas.

Figure 4

In a similar patter of expression, IRS-1 is detected by immunohistochemistry in the cytoplasm and nuclei of neoplastic cells in cases of Glioblastoma multiforme that are positive for JCV T-Antigen (upper panels). However, tumors that lack T-antigen demonstrate exclusive cytoplasmic IRS-1 (middle panels). Finally, IRS-1 can be translocated to the nucleus in the presence of Estrogen Receptor beta (lower panels). All panels original magnification 600x.