Figure 8.

Activation of syn- and ex-NMDAR leads to overlapping but not opposing genomic responses. The genome-wide expression changes after the activation of syn- or ex-NMDAR were examined by using the Affymetrix GeneChip Rat Gene 1.0 ST Arrays. (a) Venn diagram showing the number of overlapping genes upregulated or downregulated by both syn- and ex-NMDAR. The upregulated genes mediated by syn-NMDAR do not overlap with the downregulated genes by ex-NMDAR; the downregulated genes mediated by syn-NMDAR do not overlap with the upregulated genes by ex-NMDAR. (b) List of the overlapped upregulated genes and their putative transcription factors. (c) List of the overlapped downregulated genes and their putative transcription factors