Figure 5.

Transient expression of CBX1-LEDGF_325-530 retargets LV integration into CBX1-rich heterochromatin regions in X-CGD PLB cells. Correlations were made between integration sites and the density of a panel of 39 histone modifications (Figure 3c). P values showing significance of departures from mock-treated WT cells (overlaid with dashes) are shown with asterisks (***P < 0.001, Wald statistics referred to χ² distribution compared with mock). CBX1, heterochromatin protein 1β eGFP, enhanced green fluorescent protein; gp91, glycoprotein 91; LEDGF/p75, lens epithelium-derived growth factor; LV, lentiviral vector.