Table 6.
The maximal weight change percentages by water absorption at 90% and 93% relative humidity for raw versus cospray-dried cyclosporine A: dipalmitoylphosphatidylcholine/dipalmitoylphosphatidylglycerol particles for dry powder inhalation aerosol powder formulations
| Sample | wt% at 90% RH | wt% at 93% RH |
|---|---|---|
| Raw CsA | 4.33 | 4.56 |
| DPPC | 11.40 | 13.19 |
| DPPG | 3.98 | 5.47 |
| co-SD CsA:DPPC/DPPG 25:75 (1:3) | 13.26 | 14.83 |
| co-SD CsA:DPPC/DPPG 75:25 (3:1) | 11.14 | 12.24 |
Abbreviations: CsA, cyclosporine A; DPPC, dipalmitoylphosphatidylcholine; DPPG, dipalmitoylphosphatidylglycerol; RH, relative humidity; SD, spray dried; wt%, weight change percentage.