Table 11.
Drugs used for the treatment of hypertension in children and adolescents, which on the basis of their long half-life are administered once-a-day
| |
Recommended Daily Dose (mg) |
|||
|---|---|---|---|---|
| |
Body Weight (kg) |
|||
| Class | Drug name | 10-25 | 25-40 | >40 |
| Renin-Angiotensin-Aldosterone |
|
|
|
|
| System Blockers |
|
|
|
|
| AT1-receptor Blockers |
Candesartan |
4-8 |
8-16 |
16-32 |
| |
Irbesartan |
37-75 |
75-150 |
150-300 |
| |
Losartan |
12-25 |
(25)-100 |
(50)-100 |
| |
Olmesartan |
(2.5)-10 |
5-20 |
20-40 |
| |
Valsartan |
20-40 |
40-80 |
80-160 |
| ACE -Inhibitors |
Benazepril |
2.5-5.0 |
5.0-10 |
10-20
[40] |
| |
Fosinopril |
1.3-2.5 |
2.5-10 |
5.0-20
[40] |
| |
Lisinopril |
2.5-10 |
5.0-20 |
10.30
[40] |
| |
Quinapril |
2.5-5.0 |
5.0-10 |
10-20
[40] |
| |
Ramipril |
1.3-2.5 |
2.5-10 |
5.0-20 |
| Beta-Blockers |
Atenolol |
12-25 |
25-100 |
100-200 |
| |
Bisoprolol |
1.2-2.5 |
2.5-5.0 |
5.0-10 |
| |
Metoprolol |
10-25 |
25-100 |
100-200 |
| Calcium Antagonists |
Amlodipine |
2.5-5.0 |
5-10 |
10-20 |
| Thiazide Diuretics |
Chlorthalidone |
6-12 |
12-25 |
25-50 |
| Hydrochlorothiazide | 6-12 | 12-25 | 25-50 | |
Retard formulations are unsuitable as they are often badly absorbed in children (and when split in two the prolonged effect of these formulations disappears).