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. 1990 Jul;1(8):577–584. doi: 10.1091/mbc.1.8.577

Localization of platelet-derived endothelial cell growth factor in human placenta and purification of an alternatively processed form.

K Usuki 1, L Norberg 1, E Larsson 1, K Miyazono 1, U Hellman 1, C Wernstedt 1, K Rubin 1, C H Heldin 1
PMCID: PMC361596  PMID: 2078568

Abstract

Platelet-derived endothelial cell growth factor (PD-ECGF) was purified to homogeneity from human term placenta, an organ characterized by extensive angiogenesis. N-terminal amino acid sequencing revealed that placental PD-ECGF was proteolytically processed at Thr-6, in contrast to PD-ECGF purified from human platelets, which is processed at Ala-11. The purified factor stimulated porcine aortic endothelial cells as well as two choriocarcinoma cell lines. Immunohistochemical staining revealed that PD-ECGF was present in the connective tissue cells of the placenta. The possibility that PD-ECGF is involved in the development of the placenta is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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