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. Author manuscript; available in PMC: 2013 Apr 3.
Published in final edited form as: Cancer Prev Res (Phila). 2011 Jun 16;4(9):1436–1448. doi: 10.1158/1940-6207.CAPR-10-0346

Figure 1. Mammary tumorigenesis and Brca1 expression.

Figure 1

Effect of prepubertal dietary exposure to 500 ppm genistein on (A) tumor incidence in wildtype mice (n=21–22 mice/group) and (B) in Brca1+/− mice (n=25–26 mice/group), (C) hyperplastic alveolar nodules (HANs) in these mice, and (D) Brca1 mRNA levels (n=4–6 mice per group) on postnatal day 50. Means ± SEM of Brca1 mRNA are shown; bars with different letters are significantly different from each other, p<0.05. Prepubertal genistein exposure significantly reduced mammary tumorigenesis in WT mice (p<0.029), but not in Brca1+/− mice (p<0.26).