Table 1.
Summary of mutational analysis of the studied genes in breast tumor.
| Gene | Exon | Codon | Nucleotide change | Mutation status |
|---|---|---|---|---|
| hMSH2 | 8 | 453 | A1358-------T | Splice site------30bp deletion |
| 12 | SD of exon12 | Del of 11bp at 2005 | Splice defect | |
| 15 | 878 | 2633 del (AG) | Frameshift | |
|
| ||||
| MLH1 | 12 | 397 | 1190 del (T) | Frameshift |
|
| ||||
| BRCA1 | 11 | 64 | TGT-GGT | Missense |
| 392 | 1294–1333 del | Frameshift | ||
| 1252 | 3875–3878 del | Frameshift | ||
| 1656 | 5085–5103 del | Frameshift | ||
| 1773 | ACCC-ACCCC (ins) | Frameshift | ||
|
| ||||
| P53 | 4 | 72 | GGC-CCC | Missense |
| 5 | 138 | GCC-ACC | Missense | |
| 5 | 163 | TAC-AAC | Missense | |
| 5 | 161 | 1 base pair insertion | Frameshift | |
| 6 | 209 | AGA-ACA | Frameshift | |
| 7 | 245 | GGC-AGC | Missense | |
| 8 | 280 | AGA-ACA | Frameshift | |