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. 2013 Apr 3;8(4):e59335. doi: 10.1371/journal.pone.0059335

Figure 5. Rapamycin increases the apoptotic effect of several chemotherapeutics in leukemia cells in vitro (flow cytometry).

Figure 5

(a) The apoptotic effect of rapamycin (50 ng/ml) combined with other drugs. Nalm6 cells were treated for 72 h. (DOX: doxorubicin, 100 nM; VINC: vincristin, 3 nM; MTX: methotrexate, 20 nM; ARA-C: cytarabine, 10 ng/ml, CYCLO: cyclophosphamide, 500 nM; MED: methyl-prednisolone, 100 nM.) *- p<0,05. (b) The apoptotic effect of rapamycin (rap, 50 ng/ml) combined with methyl-prednisolone (med; 100 nM), vincristin (vin; 3 nM) and etoposide (eto; 10 nM) treatment in isolated childhood BCP-ALL cells from three different patients, treated for 24 h. (The first two samples were cultured from cells isolated at diagnosis, the third one at relapse).