Table 3. Association analysis between the various polymorphisms of interest and asthma phenotypes (difficult versus M/M asthma).
| Genetic variant | Associated allele | Difficult Asthmatics | M/M Asthmatics | p-value | p-value (adjusted)† |
| ADRβ2 A46 > G | A | 37.5% | 34.6% | 0.57 | - |
| CRHR1 G35892 > T | T | 34.4% | 29.4% | 0.32 | - |
| CRHR1 A38952 > G | A | 93.8% | 89.0% | 0.11 | - |
| CRHR1 G54898 > A | G | 82.0% | 78.7% | 0.44 | - |
| LTC4S A-444 > C | C | 33.3% | 29.4% | 0.43 | - |
| LTA4H A-9188 > G | A | 79.5% | 61.0% | 1×10−4 | 0.0007 |
| IL-4 C-590 > T | C | 89.1% | 88.8% | 0.93 | - |
| IL-4 C-33 > T | C | 88.7% | 88.2% | 0.88 | - |
| IL-13 C-1111 > T | T | 18.0% | 16.2% | 0.65 | - |
| IL-13 G431 > A | A | 15.9% | 15.2% | 0.86 | - |
| IL-4Rα A223 > G | A | 57.6% | 56.6% | 0.85 | - |
| IL-4Rα A1199 > C | A | 93.3% | 86.6% | 0.033 | 0.14 |
| IL-4Rα T1570 > C | T | 87.9% | 78.7% | 0.018 | 0.091 |
| IL-4Rα A1727 > G | A | 86.2% | 75.0% | 0.007 | 0.037 |
| LTA C804 > A | C | 62.5% | 56.0% | 0.22 | - |
| TNFα T-1031 > C | C | 24.6% | 17.4% | 0.11 | - |
| TNFα C-863 > A | A | 20.7% | 12.5% | 0.047 | 0.22 |
| TNFα G-308A | G | 80.8% | 66.9% | 0.004 | 0.019 |
†
Adjusted p-values were considered when the initial uncorrected values were <0.05.