Table 4. Association of the examined haplotypes with the risk of developing difficult asthma in children.

Haplotype	Frequency, % (Study Cohort)	Frequency ratio, % (Difficult:M/M)	p-value	p-value (adjusted)†
Block 1: IL-4Rα ( A1199 > C , T1570 > C and A1727 > G )
ATA	81.9%	86.2%∶75.0%	0.007	0.040
CCG	9.2%	6.7%∶13.2%	0.037	0.187
ACG	0.6%	5.4%∶8.1%	0.304	-
ATG	2.5%	1.8%∶3.7%	0.265	-
Block 2: TNFα ( C-863 > A and -308A )
CG	58.1%	60.1%∶54.9%	0.338	-
CA	24.2%	19.2%∶32.6%	0.004	0.018
AG	17.6%	20.7%∶12.5%	0.046	0.238

^†Adjusted p-values were considered when the initial uncorrected values were <0.05.