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. 2013 Apr 3;8(4):e60691. doi: 10.1371/journal.pone.0060691

Figure 3. Specificity of the olfactory deficits in α-syn mice.

Figure 3

A–B: Odor preference test. A. Description of the protocol. Two cartridges, filled with either lemon or lime are placed in the cage for 5 min. If mice do not have any odor preference they spend a similar time sniffing either cartridge. B. Percentage of time sniffing lemon and lime showing no difference between control and α-syn mice and no difference between lime and lemon odors. N = 19–21 for each group aged 10–11 months. Statistics: two-way ANOVA, odor, p = 0.57, F(1,76) = 0.33; genotype, p = 1.00, F(1,76)≈0; odors×genotype, p = 0.80, F(1,76) = 0.06). C-D Open field test. C. Distance traveled in the open field. No significant difference was observed between WT and α-syn mice. α-syn mice show similar locomotor activity to control mice. N = 10 for each group aged 10–11 months. Statistics: unpaired t-test, p = 0.088. D. Percentage of time spent in different areas. No significant difference between WT and α-syn mice (p>0.05, two-way ANOVA), suggesting each type of mouse exhibited the same level of anxiety. N = 10 for each group aged 10–11 months. Statistics: two-way ANOVA, genotype, p = 1, F(1,54) = 0; areas, p<0.0001, F(1,54) = 165.1; genotype×areas, p = 0.42, F(2,54) = 0.87; Bonferroni post-hoc between WT and α-syn mice, p>0.05). E. Rotarod test. Time spent on the rod was similar between both groups of mice. N = 10 for each group aged 10–11 months. Statistics: unpaired t-test, p = 0.9.