Figure 4. Overexpression of α-synuclein in the olfactory bulb of the α-syn transgenic mice.
Immunostaining of human wild-type α-synuclein in OB of A. WT mice and B-D. α-syn mice aged 12 months. A-B. Scale bars: 500 µm. C-D. High magnification of C. the glomerular layer (Gl) and D. the granule cell layer (GCL). Scale bars: 50 µm. α-Syn mice exhibit high expression of human α-synuclein in the different layers of the OB. α-Synuclein immunoreactivity indicates large profiles (arrows) as well as numerous small α-synuclein immunoreactive puncta (arrow heads).