Table 3.

Improvement in proteinuria by improving dipping pattern

Study	Number of patients	Intervention	Duration	Outcome
Hermida et al 200536	200	Valsartan 160 mg morning or evening	3 months	Protein excretion reduced by 41% in those receiving night dose
Hermida et al 200539	148	nondippers Valsartan 160 mg morning or evening	3 months	75% of those receiving night dose became dippers with reduction of proteinuria
Hoshino et al38	31	Amlodipine-Olmesartan combination – morning or evening	8 weeks	Urinary albumin/creatinine ratio was 42.5 ± 59.9 mg/g versus 75.3 ± 26.4 mg/g in bedtime versus daytime administration